PDE12 is 2', 5'-phosphodiesterase 12 protein that belongs to the CCR4/nocturin family. PDE12 cleaves the 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates. Triphosphorylated oligoadenylates, which are referred to as 2-5A, modulates in the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs) (1). Suppression of PDE12 induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. PDE12 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, Inflammation, and Phosphodiesterase research.
序列
该【干冰】PDE12 recombinant protein-GST fusion protein - 009-001-S85S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】PDE12 recombinant protein-GST fusion protein - 009-001-S85S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】PDE12 recombinant protein-GST fusion protein - 009-001-S85S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.