RGS1 is a member of the regulator of G-protein signaling family and attenuates the signaling activity of G-proteins. RGS1 binds to activated GTP-bound G alpha subunit and acts as a GTPase activating protein (GAP) thereby increasing the rate of conversion of GTP to GDP and terminating the signal (1). RGS1 is extensively up-regulated in renal cell carcinoma (RCC) tissues and melanoma. In melanoma, RGS1 expression is significantly correlated with increased tumor thickness, mitotic rate and presence of vascular involvement. Furthermore, there is significant association between increasing RGS1 expression and reduced relapse-free survival as well as disease-specific survival (DSS) survival (2). RGS1 Protein is ideal for investigators involved in Signaling Proteins, G-Proteins, AKT/PKB Pathway, Cancer, Cell Cycle, ERK/MAPK Pathway, Inflammation, JNK/SAPK Pathway, p38 Pathway, and PKA/PKC Pathway research.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.