UBA3 (also known as UBE1C) or ubiquitin-like modifier activating enzyme 3 is a member of the E1 ubiquitin-activating enzyme family. UBA3 associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. The mechanism of NEDD8 activation by APPBP1-UBA3 shows a high degree of conservation with ubiquitin activation by UBA1 (1). The NEDD8-activating enzyme, or NAE, composed of NAE1 and UBA3 subunits, is an essential component for the treatment of cancer disease (2). UBA3 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cancer, Cell Cycle, and Neurobiology research.
序列
该【干冰】UBA3(UBE1C), recombinant protein-GST fusion protein - 009-001-U26的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】UBA3(UBE1C), recombinant protein-GST fusion protein - 009-001-U26的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】UBA3(UBE1C), recombinant protein-GST fusion protein - 009-001-U26的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.