UCHL3 or ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) is a member of the deubiquitinating enzyme family that catalyze the removal of ubiquitin from polypeptides. The deubiquitinating enzyme family is divided into five classes, depending on the mechanism of catalysis. UCHL3 has been implicated in the etiology of neurodegeneration (1). UCHL3 may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle and UCHL3 genes contain a conserved CpG island (2). UCHL1 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Invasion/Metastasis, and Neurobiology research.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.