VAV1 is a member of the VAV gene family which are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. VAV1 activates pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. VAV1 is important in hematopoiesis, playing a role in T-cell and B-cell development and activation (1). VAV1 has been identified as the specific binding partner of Nef proteins from HIV-1. Co-expression and binding of Nef with VAV1 initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.VAV1 proto-oncogene participates in the signaling processes that mediate the antigen-induced activation of B lymphocytes (2). VAV1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, ERK/MAPK Pathway, JNK/SAPK Pathway, and p38 Pathway research.
序列
该【干冰】VAV1 recombinant protein-GST fusion protein - 009-001-U55S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】VAV1 recombinant protein-GST fusion protein - 009-001-U55S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】VAV1 recombinant protein-GST fusion protein - 009-001-U55S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.