VLK or vertebrate lonesome kinase is a protein kinase which is first expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, and later its expression is confined to E-cadherin-negative mesenchyme. VLK regulates the rate of protein export from the Golgi and thereby plays an important role in the formation of functional stroma by mesenchymal cells (1). Targeted disruption of VLK leads to a defect in lung development and delayed ossification of endochondral bone. VLK deficient mice display neonatal lethality due to respiratory failure, with a suckling defect arising from a cleft palate. VLK is required for the appropriate timing of flat proliferative chondrocyte differentiation (2). VLK Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Cytoplasmic Tyrosine Kinases, Invasion/Metastasis, Neurobiology, and Ser/Thr Kinases research.
序列
该【干冰】VLK recombinant protein-GST fusion protein - 009-001-U57S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】VLK recombinant protein-GST fusion protein - 009-001-U57S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】VLK recombinant protein-GST fusion protein - 009-001-U57S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.