12-R)-HETE Lipid Maps MS Standard, 12R-hydroxy-5Z,8Z,1E,14Z-eicosatetraenoic acid
供应商
Cayman
产品货号
10007247-250
产品报价
¥12992/250 ug
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背景资料
Biosynthesis of 12-R)-HETE in invertebrates is via lipoxygenation of arachidonic acid. In mammals, 12-R)-HETE can be produced by 12-R)-LOs and also by CYP450 oxidation. The activity of 12-R)-HETE in mammals is predominantly proinflammatory. 12-R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.