D-myo-Inositol-1,4,6-phosphate -Ins-1,4,6)-P3) is a member of the inositol phosphate -InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins-1,4,5)-P3, is a second messenger produced in cells by phospholipase C -PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins-1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins-1,4,6)-P3 -tested as the meso compound) is 9-fold less potent than Ins-1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.
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Ins-1,4,6)-P3 is a member of the InsP family that play critical roles as small, soluble second messengers in the transmission of cellular signals.{8672,8344} The most studied InsP, Ins-1,4,5)-P3, is a second messenger produced in cells by PLC-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.{2429,5714} Binding of Ins-1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.{5714,4096} Ins-1,4,6)-P3 -tested as the meso compound) is 9-fold less potent than Ins-1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.{13725}