D-myo-Inositol-1,2,3,6-tetraphosphate -Ins-1,2,3,6)-P4) is one of the many inositol phosphate -InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins-1,4,5)-P3 is a second messenger produced in cells by phospholipase C -PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins-1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins-1,2,3,6)-P3 -tested as the meso compound) is 100-fold less potent than Ins-1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.
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Ins-1,2,3,6)-P4 is one of the many inositol phosphate -InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals.{8672,8344,13727} The most studied InsP, Ins-1,4,5)-P3 is a second messenger produced in cells by phospholipase C -PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.{2429,5714} Binding of Ins-1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.{5714,4096} Ins-1,2,3,6)-P3 -tested as the meso compound) is 100-fold less potent than Ins-1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.{13725}