中文名称

-+)-AS 115 (5 mg)

英文名字

-+)-AS 115, N-[2-[[(1S,2R)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenyl ester-carbamic acid

供应商

Cayman

产品货号

10009650-5

产品报价

￥21070/5 mg

产品说明书

购买方式

产品新闻

背景资料

KIAA1363 is a 2-acetyl monoacylglyceryl ether -MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SK0V-3. Treatment of SKOV-3 cells with 10 uM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e., -+)-AS 115 and --)-AS 115, has not been determined.

产品描述

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues -IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells); activity of the individual enantiomers of AS 115, i.e,. -+)-AS 115 and --)-AS 115, has not been determined

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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