中文名称

Harmine (5 g)

英文名字

Harmine, 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole

供应商

Cayman

产品货号

10010324-5

产品报价

￥3584/5 g

产品说明书

购买方式

产品新闻

背景资料

Peroxisome proliferator-activated receptor .gamma. -PPAR.gamma.) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione -TZD) class of antidiabetic drugs. Harmine is a .beta.-carboline alkaloid that was first isolated from seeds of Peganum harmala -Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPAR.gamma. expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner. Administration of harmine -30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression -TNF.alpha., IL-1.beta., iNOS) and macrophage accumulation in adipose tissue.

产品描述

Harmine is a .beta.-carboline alkaloid that was first isolated from seeds of Peganum harmala -Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPAR.gamma. expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.{14921} Administration of harmine -30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression -TNF.alpha., IL-1.beta., iNOS) and macrophage accumulation in adipose tissue.{14921}

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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