FABP4 -human recombinant) Western Ready Control (1 ea)
供应商
Cayman
产品货号
10010463-1
产品报价
¥714/1 ea
产品说明书
购买方式
产品新闻
背景资料
Fatty acid binding protein 4 -FABP4) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation. Studies using FABP4 gene deletion in mice indicate a dominant role for FABP4 in several chronic metabolic diseases. Therefore, inhibiting the function of FABP4 is a potential mechanism for the treatment of metabolic diseases like diabetes and atherosclerosis.