Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Human Follistatin is aa 31-33 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.
应用类型
WB, IHC (P)
免疫原
该Anti-Human Follistatin的详细信息查看ReliaTech提供的产品说明书。
来源宿主
该Anti-Human Follistatin的详细信息查看ReliaTech提供的产品说明书。
反应性
该Anti-Human Follistatin的详细信息查看ReliaTech提供的产品说明书。
保存建议
该Anti-Human Follistatin的详细信息查看ReliaTech提供的产品说明书。溶解建议:Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.