The tumour suppressor p21Waf1 (Wild-type p53-Activated Fragment 1; also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.
应用类型
IHC(P), ICC, ELISA
免疫原
Human p21 protein
来源宿主
小鼠
反应性
Human, Non-human primates
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.