CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals leading to cellular effector functions. The isoform FcgammaRIa1 binds human IgG with high affinity, has limited myeloid cell distribution, and a relatively large intracellular domain. Products of related genes include FcgammaRIb and FcgammaRIc isoforms, but these specify low affinity IgG receptors if functionally expressed at all. Besides a role in antigen clearance, FcgammaRI (a1) can potently enhance MHC class I and II antigen presentation in vitro and in vivo.
应用类型
FC (QC tested), IP, WB, IHC(P), IHC(F), ICC
免疫原
Rheumatoid synovial fluid cells and fibronectin purified human monocytes
来源宿主
小鼠
反应性
Human, Non-human primates
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.