中文名称

重组人尼克酰胺-N-甲基转移酶（100ug）

英文名字

Nicotinamide N-Methyltransferase (human recombinant)

供应商

Cayman Chemical

产品货号

15138-100

产品报价

￥询价/100ug

产品说明书

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购买方式

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产品新闻

背景资料

Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.{24617} NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.{24616,24618,24614} Overexpression of NNMT has been reported in several cancers. Knockdown of NNMT by shRNA lowers the invasiveness of clear cell renal cell carcinoma, and slows the growth of oral squamous cell carcinoma tumors injected into mice.{24615,24613} The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.{24614,24772} Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.{24614}

产品描述

提供的重组人尼克酰胺-N-甲基转移酶（100ug）产品形式为：50 mM Tris, pH 8.0, containing 500 mM sodium chloride, 5% glycerol, and 1 mM DTT.

产品形式

Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.{24617} NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.{24616,24618,24614} Overexpression of NNMT has been reported in several cancers. Knockdown of NNMT by shRNA lowers the invasiveness of clear cell renal cell carcinoma, and slows the growth of oral squamous cell carcinoma tumors injected into mice.{24615,24613} The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.{24614,24772} Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.{24614}

保存建议

建议您在收到Cayman Chemical品牌的重组人尼克酰胺-N-甲基转移酶（100ug）产品后置于-80度保存，产品有效期为180天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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