N-十二烷酰基-NBD-L-苏糖基鞘氨醇-N-Dodecanoyl-NBD-L-threo-sphingosine代理/参数/厂家-标准品（生化）-开云·官方站线上登录平台入口

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标准品（生化）

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背景资料: This product is a fluorescent L-threo-ceramide. The NBD fluorescent group has been shown to have only a small influence on lipid adsorption into cells and cellular membranes and this fluorescent analog of L-threo-ceramide is comparable to C12:0-L-threo-ceramide in many biological functions such as lipid uptake and transport1, structural determinants, and lipid partitioning2. L-threo-ceramide is a non-natural isomer of ceramide. The natural D-erythro isomer is a critical compound in cells both as a free ceramide and incorporated into more complex sphingolipids. L-threo-ceramides demonstrate a different metabolic functionality from natural ceramides. They have been shown to be metabolized to sphingomyelin but not to glucosylceramide. Another non-natural stereoisomer, L-erythro ceramide, is not metabolized to any sphingolipid. In contrast to natural ceramides L-threo ceramides are unable to antagonize the disruptive effects of fumonisin B1 on axon growth but it is able to activate intracellular pathways and induces apoptosis.3 The deacylated form of ceramide, sphingosine, also has many critical cellular functions. L-threo-sphingosine, along with other sphingosine isomers, has been found to be an activator of 3-Phosphoinositide-dependent kinase-14 and inhibits protein kinase C a little more potently than D-erythrosphingosine.

其他: Matreya LLC是一家脂质生化公司，致力于开发和制造高质量的脂质和生物化学品。Matreya在化学合成以及天然产物提取和纯化方面经验丰富，生产出的产品具有最佳纯度。 Matreya产品线包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和维生素E异构体（生育酚和生育三烯酚）。专长是生产高纯度鞘氨醇、神经酰胺、硫酸酯、神经节苷脂、酶抑制剂、生育酚和生育三烯酚。是全球提供脂质产品最全的供应商之一。产品涉及生物化学、制药、微生物学、食品和农业等研究领域。