Bnip3L/Nix Antibody (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3-like protein X)
供应商
Biovision
产品货号
3205-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Members of Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins,including Bad,Bax,Bid,Bik,Hrk,Nip3,and Bim,form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L,Bnip3,and Nix (for Nip3-like protein X). Bnip3L/Bnip3/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes supression by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The message RNA of Bnip3L and Bnip3 form a new subfamily of the proapoptotic mitochondrial proteins.
应用类型
The antibody can be used for Western blot analysis (0.5-2 ug/ml) and immunohistochemistry (2-10 ug/ml). The optimal conditions should be determined individually. Other applications have not been tested.
免疫原
Synthetic peptide surrounding amino acid 80 of human Bnip3L.