Recombinant Human Soluble Interleukin-6 (IL-6) Receptor
供应商
Biovision
产品货号
4598-20
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产品新闻
背景资料
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).
序列
重组人可溶性白介素6受体蛋白又称soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126.其对应NCBI基因号为3570,对应Accession号为P08887.