ATG5 Antibody (NT-R) (Autophagy protein 5, Autophagy related protein 5, ATG5L, ASP)
供应商
Biovision
产品货号
5063-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5,another member of the autophagy protein family,forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1),inhibiting type I interferon production and permitting viral replication in host cells.
应用类型
Immunohistochemistry: 2.5 ug/ml; Western Blot: 1 - 2 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
ATG5 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ATG5.