LAMP-1 Antibody (Center) (LAMP-1, Lysosome associated membrane protein 1)
供应商
Biovision
产品货号
5077-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy,LAMP-2,is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thought to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However,the loss of both proteins resulted in embryonic lethality,suggesting that each protein possesses some unique and necessary functions.
应用类型
Western Blot: 1 - 2 ug/ml, Immunofluorescence: 20 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.