LAMP-2抗体（C末端）-LAMP-2 Antibody （CT）（LAMP-2， Lysosome associated membrane protein 2）代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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二抗

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背景资料: Autophagy，the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR （Target of rapamycin）. LAMP-2，a highly glycosylated protein associated with the lysosome，has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon’s disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

应用类型: Western Blot: 1 - 2 ug/ml， Immunocytochemistry: 10 ug/ml， ELISA. However， the optimal conditions should be determined individually.

免疫原: LAMP-2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LAMP-2.

保存建议: 提供的LAMP-2抗体（C末端）产品为无色溶液形式，含有100 ug抗体.该产品浓度为1 mg/ml，溶解于包含有0.02 % 叠氮化钠的PBS缓冲液中.请在收到该LAMP-2抗体（C末端）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

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