TAB2 Antibody (CT) (MAP3K7-interacting protein 2, MAP3K7IP2, CHTD2)
供应商
Biovision
产品货号
5083-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
TAB2 is an activator of MAP3K7/TAK1,which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6,MAP3K7 and TAB1,thus serves as an adaptor linking MAP3K7 and TRAF6. This protein,TAB1,and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK),which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy,these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy,while their depletion triggers it,suggesting that TAB2 and TAB3 act as a control point for autophagy.
应用类型
Immunohistochemistry: 5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
TAB2 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human TAB2.