ZNF521 Antibody (CT) (Zinc finger protein 521, EHZF, Evi3)
供应商
Biovision
产品货号
5407-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development,inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3),promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner,thereby regulating osteoblast differentiation,skeletal development,and bone homeostasis.
应用类型
IHC: 5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
ZNF521 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ZNF521.