DNA甲基转移酶3a（克隆号64B814.1）抗体-DNA Methyltransferase 3a （Clone 64B814.1） Antibody （DNMT3， DNMT3A）代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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二抗

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背景资料: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression，genomic imprinting，and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date，three families of mammalian DNA methyltransferase genes have been identified which include DNMT1，DNMT2，and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members，DNMT3a and DNMT3b，are strongly expressed in embryonic stem （ES） cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently，it has been shown that naturally occurring mutations of DNMT3b gene occur in patients with a rare autosomal recessive disorder，termed ICF （immunodeficiency，centromeric instability，and facial anomalies） syndrome.

应用类型: Western blot: 1-3 ug/ml， IF/ICC: 5 ug/ml. However， the optimal conditions should be determined individually.

保存建议: 提供的DNA Methyltransferase 3a （克隆号64B814.1）抗体产品为无色溶液形式，含有50 ug抗体.该产品浓度为与批次相关，溶解于包含有0.05% BSA和0.05%叠氮化钠的PBS缓冲液（pH 7.2）中.请在收到该DNA Methyltransferase 3a （克隆号64B814.1）抗体产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

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