AKT1抗体（N末端）-AKT1 Antibody （NT）（PKB， RAC， Protein kinase B， Protein kinase B alpha， Short PKB alpha， Proto-oncogene c-Akt， RAC-PK-alpha， RAC-alpha serine/threonine-protein kinase. ）代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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二抗

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英文名字: AKT1 Antibody （NT）（PKB， RAC， Protein kinase B， Protein kinase B alpha， Short PKB alpha， Proto-oncogene c-Akt， RAC-PK-alpha， RAC-alpha serine/threonine-protein kinase. ）

背景资料: The serine/threonine kinase Akt family contains several members，including Akt1 （also designated PKB or RacPK），Akt2 and Akt 3，which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. They have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-∫ tyrosine residues 740 and 751，which bind the subunit of the phosphatidylinositol 3-kinase （PI 3-kinase） complex. Activation of Akt1 by insulin or insulin-growth factor-1（IGF-1） results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity，and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus，Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase（s）. The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin，suggesting that the protein signals downstream of the PI kinases.

应用类型: Western blot: ~1:1000， IHC: ~1:50-1:100， FACS: ~1:10-1:50， IF: ~1:10-1:50.

免疫原: This AKT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human AKT1.

保存建议: 提供的AKT1抗体（N末端）产品为无色溶液形式，含有100 ul抗体.该产品浓度为与批次相关，溶解于包含有0.09% （W/V）叠氮化钠的PBS缓冲液中.请在收到该AKT1抗体（N末端）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

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