ANGPTL1 Antibody (NT) (ANGPTL1; ANG3; ANGPT3; ARP1; Angiopoietin-related protein 1; Angiopoietin-3; Angiopoietin-like protein 1)
供应商
Biovision
产品货号
6761-100
产品报价
¥已停产
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产品新闻
背景资料
Angptl1 (angiopoietin-like 1),also known as angioarrestin,ARP1,ANGPT3 or previously known as angiopoietin 3 (ANG3),is a member of the angiopoietin-like family. It is highly expressed in adult tissues,particularly adrenal gland,thyroid,placenta and small intestine. Angptl1 exists as a disulfide-linked dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2. Angptl1 consists of an N-terminus with a coiled-coil domain,potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regulation of angiogenesis; inhibiting proliferation,migration,tube formation and endothelial cell adhesion. To exert this inhibitory activity,Angptl1 is speculated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues,Angptl1 expression is down-regulated suggesting that a major function of this protein involves its antiangiogenic properties.
应用类型
Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10–1:50.
免疫原
This ANGPTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-44 amino acids from the N-terminal region of human ANGPTL1.