BMPR2 Antibody (NT) (BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II)
供应商
Biovision
产品货号
6780-100
产品报价
¥已停产
产品说明书
购买方式
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产品新闻
背景资料
BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-B ligands that modulate gastrulation,neurogenesis,chondrogenesis,interdigital cell death,and bone morphogenesis. In contrast to the TGF-B type II receptor,BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension,inflammation,and endothelial injury.
应用类型
WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
免疫原
This BMPR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the N-terminal region of human BMPR2.