RARA polyclonal antibody (Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, NR1B1)
供应商
Biovision
产品货号
6826-50
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
RARA is a receptor for retinoic acid,a vitamin A metabolite,which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand,this receptor represses transcription through the recruitment of specific corepressors and of HDAC’s,whereas binding of retinoic acid causes the recruitment of coactivators and HAT’s. Translocations involving the RARA gene,often leading to a RARA/PML fusion protein,are a major cause of acute promyelocytic leukemia.
应用类型
ChIP: 4 ug/ChIP, WB: 1:750, ELISA: 1:50.
免疫原
Human RARA (Retinoic Acid Receptor alpha) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein.