Matrix metallopeptidase 9 (MMP-9) is secreted from neutrophils, macrophages and a number of transformed cells. It is the most complex MMP family member in terms of domain structure and regulation of its activity. MMP family is involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes. Most MMPs are secreted as inactive pro-proteins which are activated by the cleavage of extracellular proteinases. MMP-9 degrades various substrates including gelatin, collagen types IV and V, and elastin. It is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and diseases including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. MMP-9 is regarded as a potential therapeutic target and a biomarker of disease status.
序列
提供的Human CellExp™MMP-9,人类重组Human CellExp™ MMP-9, human recombinant是Biovision品牌中国区域总代理艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。
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溶解建议
Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.