Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X(S) promotes apoptosis.
序列
重组人(生物活性)Bcl-2样蛋白1又称Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX.其对应NCBI基因号为598,对应Accession号为Q07817.
来源宿主
提供的【BCL2L1】重组人(生物活性)Bcl-2样蛋白1蛋白产品来源为大肠杆菌中重组表达.
溶解建议
提供的重组人(生物活性)Bcl-2样蛋白1产品为固体冻干粉形式.推荐使用去离子水溶解,储存浓度为200 ug/mL. 室温下溶解30-60分钟,期间轻轻混匀.长期保存和进一步稀释的时候,推荐添加载体蛋白(0.1% (W/V) HSA or BSA).