MenoCheck picoAMH ELISA-MenoCheck picoAMH ELISA代理/参数/厂家-ELISA试剂盒-开云·官方站线上登录平台入口

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中文名称: MenoCheck picoAMH ELISA

英文名字: MenoCheck picoAMH ELISA

供应商: Ansh Labs

产品货号: AL-124

产品报价: ￥询价/96wellmicrotiter

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背景资料: Menopause is the cessation of menstrual cycling and fertility. Clinically it is recognized by a cessation of menstrual bleeding; menopause is a woman’s status after her final menstrual period (FMP). Menstrual cycling and bleeding are driven by the dynamics of ovarian follicle maturation. Because a woman is born with a limited number of follicles (non-growing “primodial” follicles) that cannot be replaced and are slowly consumed by the monthly maturation of smaller groups of follicles (primary, secondary and antral growing follicles), the natural cause of menopause is the absence of follicles. However, many natural (e.g., certain diseases, starvation, etc.) or interventional processes (chemotherapy, surgical removal of the uterus, ovaries, or pituitary gland, etc.) can cause a cessation of menses that can be either irreversible (e.g., functionally the same as menopause) or reversible. Diagnosing menopause (e.g. the FMP) currently is only done unequivocally after cessation of menses for 12 months in a previously cycling woman.
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nNaturally occurring (i.e., as a result of aging) menopause is referred to as “spontaneous” and, on average, occurs at the age of 51 years, but there is a very large variance of approximately +/- 10 years with respect to the occurrence of menopause in healthy women. Ovarian function deteriorates gradually leading up to menopause and contributes to the variance observed among women with respect to menopausal status. Ovarian function affects, primarily via the steroid hormones produced by growing follicles, virtually every organ in a woman’s body. Physiological responses to the gradual or abrupt loss of ovarian function include a multitude of menopausal “symptoms” and consequences that affect a woman’s health and quality of life. 1,2
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nDuring several years leading up to the FMP and several years immediately following the FMP is a time called the climacteric or menopausal transition, when a woman transitions from the reproductive to a non-reproductive state. The transition is highly variable among women with respect to duration and intensity of associated physiological changes, which affect her well being and level of disease risk. Thus, determining where a woman is in this process must be individualized and is clinically important, particularly during the menopausal transition and the 12 months following the FMP. Quantitative measurement of blood levels of Anti-Müllerian Hormone using the picoAMH assay can aid in determining a woman’s menopausal status during the menopausal transition.
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nBlood levels of AMH represent one of the markers available to clinicians to determine where a woman is in her menopausal transition. Other clinical tests relevant in this context are estradiol which is produced only by follicles in their final stages of maturation, and thus only indirectly reflects the total number of follicles in the ovary, and FSH which reflects the negative feedback by estradiol on pituitary gland secretion (i.e., also an indirect marker of ovarian follicular pool based on large follicle function). In contrast AMH is produced by the majority of ovarian follicles (primary, secondary and antral).
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nBlood levels of AMH have been shown to be highly correlated with the number of primordial follicles in an ovary (i.e., true ovarian reserve).3 The picoAMH assay was developed to allow more sensitive measurements. AMH measured using the picoAMH assay provides a significant new parameter to aid physicians in determining the status of women during the menopausal transition.
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nREFERENCES
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n1. Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ 2015 Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 100:3975-4011
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n2. Su HI, Freeman EW 2009 Hormone changes associated with the menopausal transition. Minerva Ginecol 61:483-489

产品描述: The MenoCheck® picoAMH ELISA is FDA cleared for in vitro diagnostic use as an aid in the determination of menopausal status in women between 42 and 62 years of age. This is the only AMH test with the sensitivity to quantify declining AMH concentrations in women who are entering their menopausal transition. n n n nResearch Use Only and CE versions are available.

产品特点

保存建议: Store at 2 to 8°C until expiration date.

其他: Ansh labs是开发和生产免疫检测试剂盒和定制生物技术检测产领创者，总部位于美国休斯敦，公司产品遍及全球80多个国家。公司于2011年成立，核心团队来自于Diagnostic system laboratory，专注于女性健康和激素检测领域近40年，拥有全球领先的核心技术，以及多年经验生物技术研发经验的科学家团队，产品覆盖生殖健康，高危妊娠，肿瘤，糖尿病等多个疾病领域，围绕最新的免疫分析技术，多种蛋白和单克隆抗体，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等几十余种试剂产品，也同时涵盖小鼠，大鼠，狗，羊，牛等灵长类多个物种的独特的物种特异性的试剂。 Ansh labs 坐落于美国德克萨斯州，是目前世界上唯一能提供TGF-β超家族所有成员的检测公司，也是最早专注激素类产品研究和新型免疫检测技术的先驱者。优势产品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。