Amitriptyline hydrochloride, a tricyclic antidepressant, is used for a number of medical conditions including management of depressive disorder, anxiety disorder, bipolar disorder and management of chronic pain such as neuropathic pain, diabetic neuropathy, postherpetic neuralgia and fibromyalgia.
产品描述
A Blocker of L-type CaV Channels an Antagonist of 5-HT2 Serotonin Receptors and an Agonist of alpha-Adrenoceptors
产品形式
Voltage-gated L-type CaV1.2 calcium channels couple membrane depolarization to transient increase in cytoplasmic free Ca2+ concentration that initiates a number of essential cellular functions including cardiac and vascular muscle contraction, gene expression, neuronal plasticity, and exocytosis.nTricyclic antidepressants (TCAs) are known to inhibit Ca2+ currents, including the L-type CaV1.2 channel in heart myocyte and in neurons. Other known physiological targets of tricyclic antidepressants in the central nervous system are the 5-HT2 serotonin receptors and the α1-adrenergic receptors.