AMG 9810（50毫克）-AMG 9810代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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生化试剂

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背景资料: AMG 9810 (E)-3-(4-t-butylphenyl)- N-(2, 3- dihydrobenzo [b] [1,4] dioxin-6-yl) acrylamide is a potent, non-vanilloid, competitive antagonist of the vanilloid receptor 1 (TRPV1) receptor with IC50 values for human TRPV1 of 24.5 nM; rat TRPV1, 85.6 nM. Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. Furthermore, AMG 9810 blocks capsaicin- induced calcitonin gene-related peptide (CGRP) release and capsaicin-evoked depolarization in rat dorsal root ganglia neurons. Finally AMG 9810 was shown to be a potent and selective antagonist of TRPV1 that can significantly reverse thermal and mechanical hyperalgesia in an animal model of inflammatory pain1.

产品形式: AMG 9810 (E)-3-(4-t-butylphenyl)- N-(2, 3- dihydrobenzo [b] [1,4] dioxin-6-yl) acrylamide is a potent, non-vanilloid, competitive antagonist of the vanilloid receptor 1 (TRPV1) receptor with IC50 values for human TRPV1 of 24.5 nM; rat TRPV1, 85.6 nM. Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. Furthermore, AMG 9810 blocks capsaicin- induced calcitonin gene-related peptide (CGRP) release and capsaicin-evoked depolarization in rat dorsal root ganglia neurons. Finally AMG 9810 was shown to be a potent and selective antagonist of TRPV1 that can significantly reverse thermal and mechanical hyperalgesia in an animal model of inflammatory pain.

保存建议: 艾美捷为您提供的Alonmone Labs原装进口的AMG 9810 (50 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

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