TRPV5抗体（50 ul）-Anti-TRPV5代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).The TRPV subfamily consists of six members, TRPV1-6.TRPV5 (ECaC) and TRPV6 (CaT1) are unique members of the TRP family. Both are epithelial Ca2+ channels, form constitutively open channels, share high degree of homology (about 66%) with differences in the N and C-terminus. TRPV6 and TRPV5 are expressed in a 1,25-dihydroxyvitamin D3 dependent manner. In contrast to other members of the TRP family, TRPV5 and TRPV6 are highly Ca2+ selective and are expressed in Ca2+ transporting epithelia where they are assumed to have an important role in Ca2+ reabsorption. TRPV5 is preferentially expressed in kidney.

免疫原: TRPV5抗体的免疫原肽段为(C)GLNLSEGDGEEVYHF。此免疫原序列来源于715-729位氨基酸残基，该序列来源于人类TRPV5 (Accession编号为Q8NDW5)。胞内, C端。

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