TRPC1（胞外）抗体（25 ul）-Anti-TRPC1 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: The TRPC subfamily consists of seven proteins named TRPC1 to 7, which can be further divided into four subgroups based on their sequence homology and functional similarities:n1.) TRPC1 2.) TRPC4 and TRPC5 3.) TRPC3, TRPC6, TRPC7 4.) TRPC2. They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues.nTRPC1 was the first mammalian TRP protein that was reported to form an ion channel. It can co-assemble with other TRPC subunits (TRPC3, TRPC4, TRPC5) to form heterotetramers whose properties are distinct from that of their homomeric form. The existence of the TRPC1 homomers has not been established as ye.nThe TRPC1, TRPC4 and TRPC5 can be activated either by Ca2+, store depletion or by GPCR stimulation pathways, while TRPC3, TRPC6 and TRPC7 form non-selective cationic channels that are activated by the stimulation of GPCRs. TRPC1, 4 and TRPC5 are assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular smooth muscle cells.

免疫原: TRPC1 (胞外)抗体的免疫原肽段为(C)SMGQMLQDFGK。此免疫原序列来源于495-505 位氨基酸残基，该序列来源于大鼠TRPC1 (Accession编号为Q9QX01)，第二胞外环。

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