连接蛋白43抗体（50 ul）-Anti-Connexin-43代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Connexins (Cx) are integral membrane proteins consisting of four transmembrane domains, two extracellular loops, one intracellular loop and intracellular N- and C-termini. The 21 members belonging to this family form homomeric or heteromeric hexamers generally termed connexons or hemi-channels. In turn, these hemi-channels further assemble in a head-to-head manner, thus forming gap junction channels. Connexins are ubiquitously expressed and their activity is regulated at the expression level and by post-translational modifications. For example, Connexin-43 (Cx43) protein level is regulated by its turnover rate and by phosphorylation of various residues which ultimately determines its activity rate.nGap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells3. They play important roles in different biological processes. These include differentiation, cell cycle synchronization, cellular development, neuronal activity and the immune response.Due to their important roles, mutations in connexins are linked with a number of diseases such as neurodegenerative disorders, skin diseases, deafness, and developmental abnormalities.

免疫原: Connexin-43抗体的免疫原肽段为(C)HAQPFDFPDDNQNSK。此免疫原序列来源于 331-345位氨基酸残基，该序列来源于人类Connexin-43 (Accession编号为P17302)。胞内, C端

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