GABA（A）Alpha1受体（胞外）-ATTO-488抗体（50 ul）-Anti-GABA （A) Alpha1 Receptor （extracellular)-ATTO-488代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: GABA（A）Alpha1受体（胞外）-ATTO-488抗体（50 ul）

英文名字: Anti-GABA （A) Alpha1 Receptor （extracellular)-ATTO-488

供应商: Alomone

产品货号: ALO-AGA-001-AG-50

产品报价: ￥已停产

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产品新闻

背景资料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.3 Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.nGABAARs are heteropentamers, in which all five subunits contribute to pore formation. To date, eight subunit isoforms have been cloned:α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunit isoforms have been found to exist in mammals (α1-α6). In most cases, native GABAA receptors consists of 2α, 2β, and 1δ subunits. The α subunit is the most common and is expressed ubiquitously. It determines the affinities of GABAARs for allosteric ligands.nEach subtype has a unique regional expression in the brain, and individual neurons often express multiple subtypes.The α1 subunit is highly expressed in adulthood while the α2 subunit is highly expressed very early in rat brain development. Failure to complete the normal transition between the α-subunits that are highly expressed in early development (α2, α3, and α5) and those expressed in adulthood (α1) is suggested to play a major role in the development of temporal lobe epilepsy. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-488 label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC.

应用类型: 经验证，该抗体可应用于IC、IH、LCI等实验。

免疫原: GABA (A) Alpha1 受体 (胞外)-ATTO-488抗体的免疫原肽段为QPSQDELKDNTTVFTR(C)。此免疫原序列来源于28-43 位氨基酸残基，该序列来源于大鼠GABA (A) α1 受体 (Accession编号为 P62813)。胞外，N端。

来源宿主: 兔

反应性: 反应性：小鼠、大鼠、也可反应于：人

保存建议: 艾美捷为您提供的GABA (A) Alpha1 受体 (胞外)-ATTO-488抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。