GABA（A）Alpha3受体（胞外）抗体（25 ul）-Anti-GABA （A) Alpha3 Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: The neurotransmitter GABA (γ-aminobutiric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.nThere are two major types of GABA receptors: the ionotropic GABAA receptors (GABAAR) and the metabotropic GABAB receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily.nGABAARs are heteropentamers, in which all five subunits contribute to formation of the pore. Eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunits isoforms (α1-α6) have been shown to exist in mammals.In most cases, the native GABAA receptors consist of 2α, 2β, and 1γ subunits. nThe α3-subunit is highly expressed during development (along with α2 and α5) and then declines in adulthood, where the α1-subunit becomes predominant. The failure to complete this switch could be a major predispositional factor in the development of temporal lobe epilepsy.

免疫原: GABA (A) Alpha3 受体 (胞外)抗体的免疫原肽段为QGESRRQEPGDFVKQ(C)。此免疫原序列来源于29-43位氨基酸残基，该序列来源于人类GABA (A) α3 受体 (Accession编号为P34903)。胞外，N端。

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