GABA（A）Alpha6受体（胞外）抗体（50 ul）-Anti-GABA （A) Alpha6 Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.nThe GABA transmitter interacts with two major types of receptors: ionotropic GABA(A) and the metabotropic GABA(B) receptors. The GABA(A) receptor belongs to the ligand gated ion channel superfamily.nThe GABA(A) R, is a heteropentamer, with all of its five subunits contributing to the pore formation. nTo date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunit isoforms were described to exist in mammals (α1-α6). The native GABA(A) receptor, in most cases, consists of 2α, 2β and 1γ subunit. The α subunit is the most common subunit and is expressed ubiquitously. nIt determines the affinities for allosteric ligands shown by GABA(A)R. nA possible role for the GABA(A) receptors in alcohol action has been derived from animal studies, in vitro cell models and human research which suggested an important role for GABA(A) α6 along with β2, α1 and γ2, in alcohol related phenotypes.nIn Canavan disease (inherited leukodystrophy), low level of expression of GABA(A) α6 was reported.

免疫原: GABA (A) Alpha6 受体 (胞外)抗体的免疫原肽段为QLEDEGNFYSENVSRILDN(C)。此免疫原序列来源于20-37 位氨基酸残基，该序列来源于大鼠GABA(A) α6 受体 (Accession编号为 P30191)。 Extracellullar, N端

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