GABA（A）Gamma2受体（胞外）抗体（50 ul）-Anti-GABA （A) Gamma2 Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: The neurotransmitter GABA (γ-aminobutyric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 There are two major types of GABA receptors: the ionotropic GABAA (GABAA R) and the metabotropic GABAB receptors. nGABAA R belongs to the ligand gated ion channel superfamily.It is a heteropentamer, with all of its five subunits contributing to the pore formation. To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.The native GABAA receptor, in most cases, consists of 2α, 2β and 1γ subunit. Three γ subunits genes have been identified in mammals. The binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance, resulting in inhibition of neural activity.nRecently, a genetic linkage between familial epilepsy syndrome and mutations in the γ2 subunit of the GABAA receptor have been demonstrated.

免疫原: GABA (A) Gamma2 受体 (胞外)抗体的免疫原肽段为QKSDDDYEDYASNKT(C)。此免疫原序列来源于39-53 位氨基酸残基，该序列来源于大鼠GABA(A) γ2 受体 (Accession编号为 P18508)。胞外，N端。

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