Kir2.1抗体（25 ul）-Anti-Kir2.1代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: Kir2.1 is a member of the family of inward rectifying K+ channels. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.Kir2.1 is a member of the Kir2.x subfamily that includes four members (Kir2.1- Kir2.4) that are characterized by strong inward rectification and high constitutive activity.nKir2.1 is expressed in a variety of tissues including heart, brain, vascular smooth muscle cells and skeletal muscles.nIn heart, Kir2.1 is a molecular component of the IK1 current that is responsible for setting the resting membrane potential, preventing membrane hyperpolarization due to Na+ pump activity, influencing propagation velocity, altering the electrical space constant, and promoting late phase repolarization.2 In fact, mutations in Kir2.1 channels have been linked to a form of long QT syndrome (LQT7) known as Andersen's syndrome that is characterized by cardiac arrhythmias, periodic paralysis, and dysmorphic features.

免疫原: Kir2.1抗体的免疫原肽段为(C)NGVPESTSTDTPPDIDLHN。此免疫原序列来源于392-410位氨基酸残基，该序列来源于人类Kir2。1 (Accession编号为P48049)。胞内, C端。

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