Ghrelin受体（胞外）抗体（50 ul）-Anti-Ghrelin Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Ghrelin is a 28 amino acid peptide, acylated on a serine residue which is essential for its biological activity1,2. In rodents, an additional form of the peptide could be purified. The peptide is released from the stomach and exerts its effect to ghrelin receptor (GHS-R). GHS-R is a member of the G-protein coupled receptor (GPCR) superfamily. Like all members, the receptor has seven transmembrane spanning domains and upon activation it stimulates phospholipase C, thereby increasing IP3 and intracellular Ca2+ levels.GHS-R is expressed in the hypothalamus, pituitary and hippocampus.nSome of the actions of ghrelin include the stimulation of growth hormone release, food intake, fat accumulation, regulation of memory and learning, activation of reward-related pathways and neuroprotection to name a few.nGHS-R 1b is a truncated form of the full length receptor which is also expressed. Although its exact functions are unknown, it is believed that it may be involved in downregulating signaling from the full length receptor. In addition, it is overexpressed in lung cancer where it dimerizes with neurotensin receptor

免疫原: Ghrelin 受体 (胞外)抗体的免疫原肽段为CRATEFAVRSG。此免疫原序列来源于 197-207 位氨基酸残基，该序列来源于大鼠Ghrelin 受体 (Accession编号为O08725)第二胞外环。

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