人类LPA5受体（胞外）抗体（50 ul）-Anti-Human LPA5 Receptor （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: LPA (lysophosphatidic acid) mediates cellular differentiation, growth, survival and motility through two subgroups of G-protein coupled receptors (GPCRs): The Edg (endothelial differentiation gene) family – LPA1, LPA2, LPA3 and the non-Edg family – LPA4, LPA5, LPA6.nLike all GPCRs, LPA receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail.nAlkyl-LPA, commonly found in platelets activates LPA5, thus explaining the high expression of the receptor in platelets. LPA is expressed in astrocytes, and sensory and motor neurons in the spinal cord. It is also detected in spleen, heart, placenta, lliver and colon.nLPA5 activation leads to cAMP production; however, it does so in a Gs independent manner4,5. The receptor couples Gq, thus leading to Ca2+ mobilization.nActivation of LPA5 was also shown to initiate neuropathic pain in mouse models. LPA5 knockout mice do not develop neuropathic pain

免疫原: Human LPA5 受体 (胞外)抗体的免疫原肽段为(C)RSKLVAASVPARDRVR。此免疫原序列来源于261-276位氨基酸残基，该序列来源于人类LPA5 受体 (Accession编号为Q9H1C0)。

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