NT3抗体（50 ul）-Anti-NT3代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF.2 The rat and human forms of Neurotrophin-3 (NT-3) are 96% homologous. nNT-3 has been shown to strengthen synaptic connections to motoneurons in the neonatal rat,3 to serve as an anti-inflammatory factor, to suppress microglial activation,4 to play a critical role in regulating T helper 1/T helper 2 cell balance5 and to modify potassium currents in isolated inner hair cells from guinea pig cochlea.6 The biological effects of NT-3 are mediated by two receptors: TrkC, which is specific for NT-3, and p75NTR, which binds all the neurotrophins

免疫原: NT3抗体的免疫原肽段为GEIKTGNSPV(C)。此免疫原序列来源于39-48 位氨基酸残基，该序列来源于成熟人类NT-3 (residues 177-186 of the NT-3 precursor) (Accession编号为P20783)。

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