proNGF抗体（25 ul）-Anti-proNGF代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Neurotrophins are synthesized as pro-forms that can be cleaved either intracellularly to release mature, secreted ligands, or extracellularly by various proteases such as plasmin, furin, PC1/3, PC7, and PACE 4.1,2,5 The immature precursor has a prodomain of 103 amino acids, which was thought to have a role in the folding and sorting of the mature NGF into the various secretion pathways. nIt was recently reported that proNGF, binds p75NTR receptor preferentially over TrkA, and this selective binding of proNGF to p75NTR leads to apoptotic death of cells that express both TrkA and p75NTR. However, mature NGF binds and activates both receptors, with resulting promotion of cell survival due to the TrkA-mediated survival signal overriding p75NTR -mediated apoptotic signal

免疫原: proNGF抗体的免疫原肽段为(C)SPRVLFSTQPPPTSSDTLDLD。此免疫原序列来源于84-104 位氨基酸残基，该序列来源于大鼠NGF (precursor) (Accession编号为 P25427)。 Pro 结构域 of the NGF蛋白。

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