Nociceptin受体-ATTO-594抗体（50 ul）-Anti-Nociceptin Receptor-ATTO-594代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Nociceptin/orphanin FQ (N/OFQ), a 17 amino acid peptide, is the endogenous agonist of the nociceptin/orphanin FQ peptide (NOP) receptor (previously termed ORL1 receptor) which belongs to the class A (Rhodopsin-like) γ subfamily of G protein-coupled receptors (GPCRs). Like all members the receptor has a common seven-transmembrane helical structure and is coupled predominantly to heterotrimeric Gi/Go proteins. N/OFQ receptor shows a high degree of structural homology with the μ-, δ- and κ-opioid receptors1. The intracellular events triggered by the binding of N/OFQ with the NOP receptor include inhibition of adenylyl cyclase, activation of phospholipase C (PLC) and of K+ channels, inhibition of Ca2+ channels, and activation of mitogen-activated protein-kinases (MAPKs). In neural tissues, the main effect is the inhibition of the release of neurotransmitters (acetylcholine, catecholamines, GABA, glutamate, 5-hydroxytryptamine, tachykinines

免疫原: Nociceptin 受体-ATTO-594抗体的免疫原肽段为(C)HREMQVSDRVRSIAKD。此免疫原序列来源于337-352 位氨基酸残基，该序列来源于大鼠nociceptin 受体 (Accession编号为P35370)。胞内, C端。

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