KV10.1（EAG-1）抗体（50 ul）-Anti-KV10.1 （EAG-1)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: KV10.1 is a member of the Ether-a-go-go family of voltage-activated K+ channels. To date, the family includes 8 members: the closely related KV10.2 (EAG-2) protein, the KV12 (elk) subfamily (elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3). As with the other KV superfamily members, KV10.1 shows the characteristic 6 transmembrane domains with intracelullar N and C termini.nThe KV10 subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. Its expression is normally confined to the brain where its physiological function has not yet been clarified.nIntriguingly, the KV10.1 channel has been implicated in malignant tumor development. It has been shown that KV10.1 was inappropriately expressed in several cancer cell lines. Moreover, one study showed that KV10.1 by itself had oncogenic potential, as a cell line transfected with the channel, induced aggressive and faster tumor growth in vivo as compared to a cell line transfected with an unrelated KV channel.

免疫原: KV10.1 (EAG-1)抗体的免疫原肽段为GDPAKRKGWARFKDAC。此免疫原序列来源于802-817 位氨基酸残基，该序列来源于大鼠KV10。1 (Accession编号为Q63472)。胞内, C端。

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