KV9.1（胞外）抗体（50 ul）-Anti-KV9.1 （extracellular)代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: K+ channels belonging to the K V9 subfamily resemble to the delayed-rectifier class of K+ channel a subunits. These channels include six transmembrane domains, an ion selective pore, a leucine zipper and positively charged amino acids in S4 the voltage sensor domain. Interestingly, both KV9.1 and KV9.3 channels are electrically silent delayed rectifying K+ channels. However, they are responsible for modifying the activity of other K+ channels such as that of KV2.1, yielding currents different from those of KV2.1 on its own.nKV9.1 is mainly expressed in the brain, human lens epithelial cells, kidney, prostate and testis. That of KV9.3 is more generalized and ubiquitous.nInterestingly, a polymorphism in the gene encoding for KV9.1 was identified and associated with high risks of suffering from neuropathic pain3. Evidently, additional work needs to be done to evaluate and decipher the role of KV9.1 (if at all) in chronic pain states.

免疫原: KV9.1 (胞外)抗体的免疫原肽段为(C)EDVRDDPVLRRLE。此免疫原序列来源于233-245 位氨基酸残基，该序列来源于大鼠KV9。1 (Accession编号为O88758)，第二胞外环。

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