NaBeta2抗体（25 ul）-Anti-NaBeta2代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: The NaV β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems.n NaV β-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane signaling, and cell adhesion molecules.nIn the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit.This association appears to be a late event in sodium channel biosynthesis.n Expression of β2-subunits increases in sensory neurons following nerve injury. β2 deficient mice develop less mechanical allodynia in compare to wild type mice, suggesting a role for β2 subunit in pain sensation

免疫原: NaBeta2抗体的免疫原肽段为(C)KTEEEGKTDGEGNAEDGAK。此免疫原序列来源于197-215 位氨基酸残基，该序列来源于大鼠β2 subunit of voltage-gated Na+ channels (Accession编号为 P54900)。胞内, C端。

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